Mechano-immunomodulatory Strategies for Bone Fracture Repair

Project Overview

This PhD project focuses on mechano-immunomodulatory strategies to enhance bone fracture repair, addressing the growing health challenge posed by osteoporosis-related fractures. By exploring how mechanical forces modulate the immune response, particularly macrophage phenotype and function, it aims to uncover novel mechanisms underpinning effective bone healing.

What You Will Do

The research involves two complementary PhD positions within the Hoey Lab. Position one explores macrophage mechanotransduction via mechanosensitive ion channels and G-protein-coupled receptors (GPCRs). Position two investigates macrophage mechanosignalling mediated by extracellular vesicles. Students will utilize advanced immune cell culture, bioreactor systems, extracellular vesicle analysis, and biomaterials engineering techniques.

Expected Outcomes

The project seeks to develop mechano-immunomodulatory materials designed to improve clinical bone repair by actively modulating the immune environment. Outcomes will deepen understanding of bone regeneration mechanisms and foster the creation of next-generation biomaterials that enhance the healing process.

Why This Matters

Osteoporosis-related fractures impose significant morbidity, mortality, and economic burdens. Current treatments often fail to address inflammation-driven impaired healing. This multidisciplinary research has the potential to revolutionize fracture treatment through innovative strategies that integrate biomechanics and immunology, ultimately improving patient recovery and reducing healthcare costs.