UOB
Modelling stroke progression and treatment in the brain
✓ Funded (Competition)
🎓 Applied Mathematics
🎓 Biomedical Engineering
🎓 Engineering Mathematics
🎓 Mathematical Modelling
blood flow
brain modelling
clinical data analysis
computational modelling
ischaemic stroke
oxygen transport
predictive modelling
stroke
This PhD develops computational models to simulate stroke progression and treatment, incorporating individual patient factors to improve predictive accuracy and support targeted clinical interventions.
Project Description
Ischaemic stroke, the disease that occurs when a clot blocks a large blood vessel in the brain, causing brain tissue to die, remains a common cause of death and a leading cause of disability. Computational models of stroke development can help to determine the best treatment options, and to understand the specific factors that lead to different outcomes in different patient groups. We have been developing models of blood flow, oxygen transport, and fluid transport in the human brain for a number of years, and the goal is now to expand these models to simulate different population groups such that we can help clinicians to target treatments in a more focussed way.
As part of an EU-wide project (https://www.geminiproject.eu
), a large consortium of groups across many different disciplines have been working to develop and to validate these models. As part of this PhD, we will move our existing models from population-averaged behaviour to individual behaviour through the inclusion of parameters such as age, sex, and medical history, to improve the predictive capability of these models. There will be extensive opportunities for collaboration across the consortium and also the opportunity to get involved with analysis of large clinical datasets and/or the construction of statistical models of outcome.
Entry Requirements
Applicants should have, or expect to achieve, at least a 2.1 honours degree in mathematics, engineering, biomedical engineering, or a related quantitative discipline.
How to Apply
Apply online through the University of Bristol postgraduate research application portal. Contact Prof Stephen Payne for further information (email via university website).
Eligibility
UK/Home
EU
International
Supervisor Profile
PS
Prof Stephen Payne
University of Bristol, School of Engineering Mathematics and Technology
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