LU
Right Ventricular Remodelling Following Pulmonary Valve Implantation in Patients with Surgically Corrected Tetralogy of Fallot (Ref: FP-SK-2025)
✓ Fully Funded
⏰ Closing Soon
🎓 Bioengineering
🎓 Biomechanics
🎓 Biomedical Engineering
🎓 Biophysics
🎓 Computational Physics
computational fluid dynamics
Tetralogy of Fallot
biomechanics
cardiac modelling
electrophysiological modelling
finite element modelling
haemodynamics
heart valves
patient-specific modelling
pulmonary valve replacement
right ventricle
This PhD develops patient-specific multiphysics computational models to study the anatomy, biomechanics, haemodynamics, and electrophysiology of the right heart before and after pulmonary valve replacement in patients with surgically corrected Tetralogy of Fallot (TOF). The goal is to predict right ventricular remodelling and adaptation post-surgery and support individualized clinical decision-making.
Project Description
Severe pulmonary regurgitation is a key indication for pulmonary valve replacement in TOF patients. The heart’s adaptation and remodelling following surgery, particularly in paediatric patients, remains poorly understood. This project aims to fill this gap by creating validated 3D computational models that serve as prognostic tools for short- and long-term outcomes after valve replacement.
Key objectives include:
Develop patient-specific multiphysics models of the right heart, incorporating anatomy, biomechanics, haemodynamics, and electrophysiology.
Assess and quantify the effects of anatomical changes and consequent right ventricular remodelling post-valve replacement.
Perform multivariate parametric analyses to explore how geometric, biomechanical, haemodynamic, and electrophysiological factors influence post-operative heart function.
Provide insights for patient-specific surgical planning and prosthesis selection.
Entry Requirements
Minimum 2:1 honours degree (or international equivalent) in Mechanical Engineering, Biomedical Engineering, Physics, or related field.
Relevant Master’s degree advantageous.
Must meet minimum English language requirements.
Relevant Master’s degree advantageous.
Must meet minimum English language requirements.
How to Apply
Apply online through the Loughborough University portal. Select Campus: Loughborough, Programme: Mechanical and Manufacturing Engineering, and quote reference FP-SK-2025 under Finance. Include a personal statement, CV, two referees, certified degree certificates and transcripts. Submission of a research proposal is optional.
Contact email: ws.phdadmin@lboro.ac.uk
Contact email: ws.phdadmin@lboro.ac.uk
Eligibility
UK/Home
EU
International
Supervisor Profile
PS
Prof Sotiris Korossis
Loughborough University, Wolfson School of Mechanical, Electrical and Manufacturing Engineering
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