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AUB

Undergraduate/Graduate Research Assistantship on AI and Machine Learning for Protein Modeling

Self-funded 🎓 Artificial Intelligence 🎓 Computational Biology 🎓 Computer Science machine learning deep learning bioinformatics computational biology large language models protein modeling python nsf grant

Explore AI applications in protein modeling and bioinformatics. Develop machine learning solutions with Python and contribute to advancing biomedical research. Gain valuable experience working under an NSF Expand AI grant.

AI-generated overview

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Why This Research Matters

This research improves protein structure predictions, crucial for drug discovery and understanding diseases such as COVID-19. Enhancing AI methods in computational biology accelerates biomedical innovation and provides tools for complex biological problems.

Computational biology Bioinformatics Machine Learning Data Science

Project Description

Project Overview

This project involves research in AI and machine learning under an NSF Expand AI grant, focusing on applications such as protein modeling, deep learning, and large language models. The work includes computational biology and bioinformatics, with goals to improve protein structure prediction and related tasks using advanced AI approaches.

What You Will Do

As a research assistant, you will develop machine learning pipelines using Python, work with deep learning models, and potentially contribute to projects involving large language models (LLMs). You will apply computational and statistical techniques to biological datasets and collaborate with team members on research publications and experiments.

Expected Outcomes

The project aims to enhance the accuracy of protein model quality estimation and homologous protein detection using deep learning frameworks. Results will contribute to improved understanding of protein structures, which is critical for advancements in biology and medicine.

Why This Matters

Improved protein modeling holds key benefits for drug design, disease understanding, and bioinformatics. Advancing AI methods in these areas accelerates scientific discovery and helps address biological challenges including viral diseases such as COVID-19.

Entry Requirements

Proficiency in Python is required. Experience in machine learning, deep learning, or large language models is preferred. Suitable for undergraduate or graduate students.

How to Apply

Email your CV/resume to sbhatta4@aum.edu to express interest.

Eligibility

UK/Home
EU
International

Supervisor Profile

DS
Dr. Sutanu Bhattacharya
Auburn University at Montgomery
300 Citations
12 h-index
Google Scholar

Dr. Sutanu Bhattacharya is an Assistant Professor of Computer Science at Auburn University at Montgomery. His research integrates computational biology, bioinformatics, and machine learning to develop advanced methods for protein structure modeling and analysis. His work features the development of deep learning approaches to improve protein model quality estimation and weak homolog detection, with significant contributions in the field including novel algorithms and applications to viral proteins.

Key Publications

2020 38 citations
QDeep: distance-based protein model quality estimation by residue-level ensemble error classifications using stacked deep residual neural networks
2021 25 citations
Modeling SARS‐CoV‐2 proteins in the CASP‐commons experiment
2021 20 citations
Recent advances in protein homology detection propelled by inter-residue interaction map threading
2022 18 citations
DisCovER: distance‐and orientation‐based covariational threading for weakly homologous proteins
2020 16 citations
Evaluating the significance of contact maps in low-homology protein modeling using contact-assisted threading

Research Contributions

Developed QDeep, a distance-based protein model quality estimation method using deep residual neural networks.
Improves accuracy in protein model quality estimation enabling better protein structure predictions.
Contributed to modeling of SARS-CoV-2 proteins in CASP-commons experiments.
Supports understanding of viral protein structures aiding COVID-19 research and drug design.
Advanced protein homology detection using inter-residue interaction map threading.
Enables improved detection of homologous proteins with weak sequence similarity, enhancing structural biology insights.
Developed DisCovER, a covariational threading approach based on distance and orientation for weakly homologous proteins.
Provides more effective modeling tools for proteins lacking close homologues, expanding structural predictions.

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