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UNI

Computational Genomics Approaches to Understanding Human Diseases and Cancer

University of Oklahoma College of Medicine Department of Molecular Genetics and Genome Sciences
Self-funded 🎓 Bioinformatics 🎓 Genetics 🎓 Genomics bioinformatics computational biology high-throughput screening computational genomics cancer genomics multiomics crisper screen genomics software

Explore the interface of computational and experimental genomics to unravel cancer mechanisms. Develop innovative software and analyze vast omics datasets. Join a lab committed to mentorship, cutting-edge research, and scientific collaboration.

AI-generated overview

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Why This Research Matters

This research is critical for understanding complex genomic alterations in diseases such as cancer, enabling improved diagnostic and therapeutic strategies. By combining computational and experimental approaches, it accelerates the translation of genomic insights into clinical applications, ultimately improving patient outcomes.

Computational Genomics Cancer Research Multiomics Data Mining Bioinformatics Software High-Throughput Screening

Project Description

Project Overview

This project aims to advance computational genomics approaches to better understand human diseases, particularly cancer, by integrating computational modeling with high-throughput experimental techniques. Research will focus on developing novel bioinformatics software and mining public multiomics datasets creatively and knowledgeably.

What You Will Do

Students and researchers will develop bioinformatics algorithms, analyze large-scale omics datasets, and contribute to high-throughput molecular and cellular biology experiments, including methods such as CRISPR screens. The lab emphasizes strong mentorship, career development, and collaboration with top-tier scientists for producing high-quality research outputs.

Expected Outcomes

Outcomes include novel computational tools, new biological insights into disease mechanisms, and contributions to the Human Cell Atlas and cancer genomics fields. Successful candidates will achieve strong publication records, secure external fellowships, and build impactful scientific networks.

Why This Matters

Understanding the complex genomics of diseases like cancer has profound implications for diagnostics, therapeutics, and personalized medicine. This work bridges computational and experimental genomics to accelerate discoveries that can transform healthcare.

Entry Requirements

PhD applicants: bachelor’s degree in genetics, genomics, bioinformatics, or related fields with prior bioinformatics and genomics research experience; Master's-level experience favorable. Postdoctoral candidates: Ph.D. in genetics, genomics, bioinformatics, or related fields with proficiency in Linux and programming (Python, R). Experience in bioinformatics algorithm development, large-scale data analysis, or high-throughput screening is preferred but not mandatory.

How to Apply

Send CV and names of at least two referees to Qingnan Liang at qingnan-liang@ou.edu. Optional: a paragraph on your desired future research topics.

Eligibility

UK/Home
EU
International

Supervisor Profile

DQ
Dr. Qingnan Liang
University of Oklahoma College of Medicine, Department of Molecular Genetics and Genome Sciences

Dr. Qingnan Liang is a computational genomics researcher currently at the University of Oklahoma College of Medicine. He specializes in integrating computational modeling with high-throughput experiments to study human diseases, especially cancer. Previously, he was a postdoctoral associate at UT MD Anderson Cancer Center focusing on single-cell and spatial genomics and has contributed to the Human Cell Atlas project's multi-omics retina atlas. His work bridges bioinformatics and molecular biology to advance disease understanding.

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