Line-Scanning Brillouin-Raman Microscope for Fast 3D Mechano-Chemical Mapping of Biological Samples
Design a novel line-scanning Brillouin-Raman microscope to rapidly map mechanical and chemical properties in 3D. Address slow point-by-point imaging limitations and enable live biological sample studies with microscopic resolution.
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Project Description
Project Overview
Brillouin spectroscopy measures visco-elastic properties of biological materials, useful in biology, tissue engineering, and drug discovery. Raman spectroscopy probes chemical composition. Combined in confocal microscopy, these techniques allow 3D mechano-chemical mapping but are slow due to point-by-point scanning. A multiplexed line-scanning approach can speed acquisition by probing many spatial locations simultaneously.
What You Will Do
You will design and develop a line-scanning Brillouin-Raman microscopy system capable of fast mechanical and chemical mapping of biological samples in 3D with microscopic spatial resolution. Work will involve optical system design, microscopy, programming in Matlab/Python, and collaboration within a multidisciplinary research team.
Expected Outcomes
A working prototype of a line-scanning microscope system for live biological samples, enabling high-speed mechano-chemical imaging. Expected faster data acquisition and new insights into biological sample mechanics and chemistry in 3D.
Why This Matters
High-speed combined Brillouin-Raman microscopy will advance fundamental biology, tissue engineering, and drug discovery by enabling live imaging of mechanical and chemical properties of biological materials at microscopic resolution. This will overcome current limitations of slow measurement times and unlock new applications.
Entry Requirements
How to Apply
Eligibility
Supervisor Profile
Assoc Prof Irina Kabakova is an Associate Professor of Physics at University of Technology Sydney specializing in microscopy, Brillouin light scattering, biomechanics, and advanced materials. Her research centers on innovative optical methods to study mechanical properties of materials and biological samples. With a strong publication record and significant citations, she is a leading figure in Brillouin spectroscopy and optical physics.