Neurophysiology and Behaviour in Rodent Models of Neurodevelopmental Disorders
Explore how genetic mutations affect brain function using advanced neural recording methods in rodent models. Investigate neurodevelopmental disorders related to autism and intellectual disability with hands-on behavioral and electrophysiological techniques.
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Project Description
Project Overview
This project focuses on neurodevelopmental disorders that give rise to autism and intellectual disability. Despite some known genetic causes, the neurological changes underlying these conditions are poorly understood. This PhD aims to explore brain function changes using newly developed rat models of Scn2a+/-, Arid1b+/-, and Grin2b+/- genetic conditions.
Using high-density neural recordings, the project will assess neural representations of the external environment during behavior, a largely unexplored area. This research is part of the broader Autism Rats Consortium funded by the Simons Foundation, with work conducted at the University of Edinburgh.
What You Will Do
- Conduct silicone probe neural recordings in freely moving rats.
- Develop and implement behavioral tasks to assess cognitive functions.
- Analyze electrophysiological data to understand neural encoding and representation.
Expected Outcomes
The project expects to provide novel insights into how specific genetic mutations alter brain function and behavior in models of neurodevelopmental disorders, potentially informing understanding of autism and intellectual disabilities in humans.
Why This Matters
Understanding the neural basis of neurodevelopmental disorders can lead to better diagnosis and treatment strategies. Rodent models allow precise manipulation and measurement of neural activity, which is critical for unraveling complex brain-behavior relationships underlying these conditions.
Entry Requirements
How to Apply
Eligibility
Supervisor Profile
Prof Paul Dudchenko is a leading behavioral neuroscientist specializing in spatial cognition, learning, and memory. Affiliated with the University of Stirling and University of Edinburgh, his research leverages electrophysiological approaches to understand hippocampal function and neural encoding during behavior. He has extensive publications on memory-related neural processes and rodent cognitive models.