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Resolving mechanisms of cell division across the tree of life

✓ Fully Funded 🎓 Cell Biology 🎓 Microbiology 🎓 Molecular Biology molecular biology evolution microbiology archaea cell division superresolution imaging protein function live-cell imaging

Explore how cell division mechanisms vary across archaea, bacteria, and eukaryotes. Apply advanced molecular and imaging techniques to dissect archaeal cell division at a molecular level and uncover fundamental biological principles.

AI-generated overview

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Why This Research Matters

This research clarifies universal and unique cell division strategies across major life domains, enhancing evolutionary biology and microbial cell biology knowledge. Insights may facilitate novel biotechnological tools and deepen understanding of microbial growth and division relevant for health and environmental applications.

Molecular microbiology Cytoskeleton Cell divsion Archaea E. coli

Project Description

Project Overview

This project explores the principles and variations of cell division mechanisms throughout the tree of life, focusing on archaea, bacteria, and eukaryotes. It aims to elucidate how archaeal cell division functions at molecular and cellular levels and compare these mechanisms across major cell types.

What You Will Do

You will use modern molecular and cellular biology techniques, including live-cell superresolution fluorescence imaging, and perform protein function studies both in vivo and in vitro. You will join a motivated research team working on an Australian Research Council Discovery Project.

Expected Outcomes

Advances in understanding archaeal cell division mechanisms will contribute to fundamental biological knowledge and may reveal new principles applicable to other organisms, potentially informing future biotechnological or medical applications.

Why This Matters

Understanding diverse cell division strategies across life forms deepens insights into fundamental biological processes, evolutionary biology, and may enable innovative applications in microbiology and molecular biology.

Entry Requirements

Applicants must be domestic students (Australian permanent residents or New Zealand citizens) with a UTS recognized MSc (Research or Coursework with research thesis) or Bachelor Honours degree (1st Class or 2nd Class Division 1 or equivalent). Strong background in molecular or cellular microbiology and a curiosity-driven approach to fundamental research are required.

How to Apply

Applicants should send their CV and list of publications to the contact person’s email address. The position remains open until filled. Interested candidates are encouraged to apply as soon as possible. Further application details can be found on the UTS Graduate Research applications website.

Eligibility

UK/Home
EU
International

Supervisor Profile

AP
Assoc Prof Iain Duggin
University of Technology Sydney, Faculty of Science
2147 Citations
27 h-index
Google Scholar

Assoc Prof Iain Duggin is a molecular microbiologist specializing in cytoskeleton, cell division, archaea, and E. coli. He leads research focusing on fundamental cell biological processes in microorganisms, combining advanced imaging and molecular biology. He is based at the University of Technology Sydney's Faculty of Science.

Key Publications

2017 192 citations
Metabolic Adaptations of Uropathogenic E. coli in the Urinary Tract
2015 181 citations
CetZ tubulin-like proteins control archaeal cell shape
2007 146 citations
Response of the Hyperthermophilic Archaeon Sulfolobus solfataricus to UV Damage
2008 145 citations
The replication fork trap and termination of chromosome replication
2009 96 citations
Termination structures in the Escherichia coli chromosome replication fork trap

Research Contributions

Characterization of CetZ tubulin-like proteins and their role in controlling archaeal cell shape.
Provides fundamental insights into archaeal cytoskeleton dynamics influencing cell morphology.
Discovery and analysis of replication fork traps and termination structures in bacterial and archaeal chromosomes.
Enhances understanding of chromosome replication and stability mechanisms in prokaryotes.
Metabolic adaptations of uropathogenic Escherichia coli in the urinary tract environment.
Advances knowledge beneficial for developing strategies against urinary tract infections.
Investigations on response mechanisms of hyperthermophilic archaeon Sulfolobus solfataricus to UV damage.
Contributes to understanding DNA repair and survival in extreme environments.

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