Retention of Dry Eye Disease Management Formulations in the Eye
Explore the retention of ocular lubricants in dry eye disease treatment using innovative fluorophotometry. Develop clinical tools and lead trials to advance anterior eye research and improve therapeutic outcomes.
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Project Description
Project Overview
This project investigates the retention time of ocular lubricants used in dry eye disease (DED) treatment on the surface of the eye. DED affects a significant portion of adults and children, impacting primary eye care. The study explores how ingredients in preservative-free ocular lubricants influence their retention, aiming to improve management strategies.
What You Will Do
The research involves reviewing current knowledge on ocular lubricant retention, developing a novel setup using a fluorophotometer on clinical tools like a slit lamp, and leading clinical studies such as crossover or randomized trials to evaluate treatments for ocular surface and DED.
Expected Outcomes
Development of a user-friendly clinical tool to measure lubricant retention, improved understanding of formulation effectiveness, and evidence-based strategies to enhance DED treatment.
Why This Matters
Dry eye disease affects millions worldwide and represents a large pharmaceutical market. Optimizing ocular lubricant formulations and assessment methods can significantly enhance patient outcomes and reduce disease burden.
Entry Requirements
How to Apply
Eligibility
Supervisor Profile
Dr Debarun Dutta is a researcher specializing in anterior eye treatments and dry eye disease management at Aston University. His work focuses on ocular surface health and improving treatment efficacy through innovative clinical research methods including fluorophotometry. He is engaged in advancing clinical tools and therapeutic strategies for eye care.