Tumour-microplastic interaction and their role in tumour growth kinetics
Explore how microplastics influence tumour growth by combining laboratory experiments and computational simulations. Investigate their role in altering tumour mechanics to impact cancer progression.
AI-generated overview
Project Description
Project Overview
This project studies the recently discovered presence of microplastics within the tumour microenvironment (TME), focusing on their accumulation and redistribution during tumour growth. The research addresses how these microplastics alter the mechanical properties of the TME and influence tumour growth kinetics through a combination of laboratory experiments and computational modeling.
What You Will Do
The project involves multidisciplinary tasks including microfluidics, 3D printing, and computational mechanics. Candidates will conduct both in vitro laboratory experiments and in silico simulations to analyze microplastic behaviours and interactions within the TME.
Expected Outcomes
The research aims to reveal how microplastics affect cancer initiation and progression by modifying the tumour microenvironment mechanics and redistribution patterns. The findings could guide the design of improved cancer therapeutic strategies.
Why This Matters
Understanding microplastic influences on tumour growth contributes to cancer biology and biomedical engineering, addressing an emerging environmental and health concern. This knowledge could have broad implications for treatment approaches and patient outcomes.
Entry Requirements
How to Apply
Eligibility
Supervisor Profile
Dr Ean Hin Ooi is a computational modelling expert at Monash University Malaysia specializing in biomedical engineering and medical devices. His research includes bioheat transfer, fluid dynamics, and computational simulation applied to biological systems. Dr Ooi has made significant contributions to modelling the mechanical and thermal properties in biomedical contexts.