Continuous-flow 14C-LC-mass spectrometry development for the life-sciences

We are seeking an outstanding PhD candidate to help develop a uniquely powerful analytical capability exploiting a new technique for radiocarbon detection. The fate of 14C-labelled compounds is studied across the life-sciences. This project is to realise the long-held goal in these disciplines of coupling the molecular specificity of liquid chromatography (LC) with the exceptional sensitivity of radiocarbon atom counting for real-time 14C-chromatography. Drug pharmacokinetics and metabolism studies utilise the detection of tracer radiocarbon atoms incorporated into the compound, but existing technologies limit these studies. Radiometric atom-decay counting is inefficient, while atom counting mass spectrometry is usually decoupled from molecular analysis. This project addresses these limitations to enable faster and more cost-effective drug development protocols. Radiocarbon positive ion mass spectrometry (PIMS), developed at SUERC and commercialised with Thermo Fisher Scientific, will be central to the work. The project includes characterisation of LC interfaces, optimisation of spectrometer configuration, and demonstration of continuous-flow 14C-LC-MS in collaboration with ARIEL. The student will work closely with technique originators and contribute to developing next-generation analytical instruments. There will be opportunities to work with Thermo Fisher Scientific in Germany, gaining industry experience in instrument development. The project offers a highly interdisciplinary environment across chemistry, physics, and life sciences, with strong industry collaboration and career development opportunities.

Strong background in analytical chemistry, physics, or instrumentation.
Experience in mass spectrometry, ion beam systems, liquid chromatography, or laboratory data analysis is desirable but not essential.

Apply via the University of Glasgow Graduate School portal.
Ensure you:
State the project title clearly
List the primary SUERC supervisor
Select SUERC as the host department