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TTU

Postdoctoral Research on Transition Metal Catalysis with Nickel and Copper Precatalysts

✓ Fully Funded 🎓 Chemistry 🎓 Inorganic Chemistry synthetic chemistry transition metal catalysis nickel precatalysts copper precatalysts organometallic intermediates reaction optimization ni(i) complexes mechanistic study

Explore transition metal catalysis by synthesizing nickel and copper precatalysts and studying reactive intermediates. Advance fundamental knowledge of catalytic mechanisms and improve catalytic efficiency.

AI-generated overview

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Why This Research Matters

This research advances sustainable chemical synthesis by providing new catalytic methods enabling selective transformations and improved reaction efficiency. Understanding transition metal-catalyzed pathways supports pharmaceutical and material development with enhanced precision and lower environmental impact.

Transition metal catalysis

Project Description

Project Overview

This project focuses on transition metal catalysis, involving the synthesis of nickel and copper precatalysts to optimize catalytic reactions. The research explores organometallic intermediates relevant to catalysis, such as the observation or isolation of Ni(I) complexes.

What You Will Do

You will synthesize nickel and copper precatalysts, optimize catalytic reactions, and conduct mechanistic studies of organometallic intermediates to understand their role in catalysis processes.

Expected Outcomes

The project will yield new catalytic methods utilizing nickel and copper complexes and provide fundamental insights into reactive intermediates, enhancing catalytic efficiency and selectivity.

Why This Matters

Understanding and optimizing transition metal catalysis has significant implications for developing sustainable chemical processes, advancing organic and inorganic synthesis, and enabling efficient production of pharmaceuticals and materials.

Entry Requirements

Experience in synthetic organic or inorganic chemistry is required. Candidates with expertise in organometallic chemistry and mechanistic studies should highlight this in their application.

How to Apply

Applicants should email a cover letter, CV, contact information for two references, and a summary of prior research to william.whitehurst@ttu.edu. Applications are reviewed as received until the position is filled.

Eligibility

UK/Home
EU
International

Supervisor Profile

DW
Dr. William G. Whitehurst
Texas Tech University
1000 Citations
25 h-index
Google Scholar

Dr. William G. Whitehurst is a leading researcher at Texas Tech University specializing in transition metal catalysis. His work focuses on developing catalytic methods for selective C(sp3)–H bond functionalization using palladium and cobalt complexes. He elucidates detailed mechanisms involving PdII/PdIV and cobalt(III) intermediates and designs multi-component coupling strategies, contributing significantly to organometallic and synthetic chemistry.

Key Publications

2019 254 citations
Palladium-catalyzed C (sp3)–H bond functionalization of aliphatic amines
This paper developed a method for functionalizing C(sp3)–H bonds in aliphatic amines using palladium catalysis, enabling new routes for amine derivatization.
2020 187 citations
A general carbonyl alkylative amination for tertiary amine synthesis
Introduced a general strategy for the carbonyl alkylative amination to efficiently synthesize tertiary amines.
2018 94 citations
Selective Reductive Elimination at Alkyl Palladium(IV) by Dissociative Ligand Ionization: Catalytic C(sp3)−H Amination to Azetidines
Demonstrated selective reductive elimination at Alkyl Palladium(IV) intermediates enabling catalytic C(sp3)–H amination to form azetidines.
2022 48 citations
Three-component coupling of arenes, ethylene, and alkynes catalyzed by a cationic bis (phosphine) cobalt complex: Intercepting metallacyclopentenes for C–H functionalization
Showcased a cobalt-catalyzed three-component coupling to functionalize arenes via metallacyclopentene intermediates.
2019 45 citations
Carboxylate‐Assisted Oxidative Addition to Aminoalkyl PdII Complexes: C(sp3)−H Arylation of Alkylamines by Distinct PdII/PdIV Pathway
Elucidated a carboxylate-assisted oxidative addition mechanism for selective C(sp3)–H arylation of alkylamines via PdII/PdIV catalytic cycle.

Research Contributions

Developed catalytic methods for selective C(sp3)–H bond functionalization of aliphatic amines using palladium and cobalt complexes.
These methods provide new tools for constructing complex molecules with applications in pharmaceuticals and materials science.
Elucidated detailed mechanisms involving PdII/PdIV and cobalt(III) intermediates in C–H activation and functionalization.
Understanding these pathways enables more rational design of catalytic processes with improved selectivity and efficiency.
Designed multi-component coupling strategies catalyzed by cobalt complexes for the synthesis of functionalized arenes.
This expands the scope of catalytic C–H functionalization for creating diverse chemical architectures.

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