Regulation of brain fluid homeostasis by dynamic aquaporin-4 subcellular relocalisation
Explore how aquaporin-4 localization controls brain water balance using cutting-edge methods. Aim to uncover mechanisms linking water transport regulation to neurodegeneration and brain swelling, offering pathways to new treatments.
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Project Description
Project Overview
Aquaporin-4 facilitates bidirectional water movement in brain and spinal cord, controlling cell volume, extracellular space, and astrocyte migration. Its subcellular localization dynamically changes, influencing water permeability. Reduced glymphatic function and altered aquaporin-4 localization occur in ageing, stroke, injury, and sleep disruption, all risk factors for neurodegeneration. Brain and spinal cord oedema result from water influx via aquaporin-4 after insults. Modulating its subcellular relocalisation offers clinical benefits.
What You Will Do
You will use in vitro and in vivo methods alongside cutting-edge biochemical and biophysical approaches to characterize the regulation of aquaporin-4 localization in health and disease.
Expected Outcomes
Identification of mechanistic frameworks explaining brain water homeostasis and how targeting aquaporin-4 relocalization can reduce brain swelling and improve recovery after CNS injuries.
Why This Matters
The project addresses urgent clinical needs by investigating mechanisms that contribute to neurodegeneration and brain oedema, advancing potential treatments to prevent brain swelling and related neurological damage.
Entry Requirements
How to Apply
Eligibility
Supervisor Profile
Dr Philip Kitchen researches molecular physiology focusing on aquaporin water channels, especially aquaporin-4 in the central nervous system. His work examines aquaporin-4's dynamic subcellular localization and its roles in brain water homeostasis and oedema after CNS insults. He integrates biochemical, biophysical, and in vivo models to translate findings to potential therapies. Dr Kitchen is a recognized expert in aquaporin biology and neurophysiology.