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24 opportunities found

Mechanistic Insights into How KMT2D Controls Transcription, DNA Repair and Genome Stability
Aston University Dr Theo Kantidakis πŸŽ“ Cancer Biology πŸŽ“ Molecular Biology

Explore how KMT2D mutations contribute to cancer and developmental disorders by dissecting its role in transcription and DNA repair. Use cutting-edge genomic techniques to differentiate catalytic and non-catalytic tumor…

This research addresses crucial gaps in understanding how KMT2D mutations drive cancer progression and developmental syndromes like Kabuki …

1470+ citations Β· h14
Gene expression mRNA tRNA chromatin
GTP Depletion and Genome Stability: Mechanistic Insights into Mycophenolic Acid-Induced Transcriptional and DNA Damage Responses
Aston University Dr Theo Kantidakis πŸŽ“ Genetics πŸŽ“ Molecular Biology

Explore how metabolic stress from mycophenolic acid affects genome stability and transcription. Investigate DNA repair and chromatin changes with direct relevance to cancer and transplant medicine. Employ molecular biol…

This research reveals broader effects of a widely prescribed immunosuppressant on genome stability, challenging assumptions about its selec…

1470+ citations Β· h14
Gene expression mRNA tRNA chromatin
Deciphering Stress Response in Healthy Aging
Aston University Dr Zita Balklava πŸŽ“ Nursing & Health

Explore how stress granule dynamics change with age and affect organismal aging using C. elegans. Investigate molecular and physiological aging markers and stress recovery to understand mechanisms promoting healthy agin…

This research addresses critical gaps in understanding the cellular mechanisms linking stress responses to aging. By uncovering how stress …

Stress Granules Healthy Aging Proteostasis Oxidative Stress
Realist evaluation of non-pharmacological management of antipsychotic weight gain in SMI-LD dual diagnosis
Aston University Prof Ian Maidment πŸŽ“ Nursing

Explore non-pharmacological ways to manage antipsychotic-related weight gain in people with dual diagnoses of SMI and learning disabilities. Use realist review and stakeholder interviews to develop practical guidance fo…

The research addresses an urgent health disparity by finding effective ways to manage weight gain caused by antipsychotic drugs that contri…

8044+ citations Β· h41
Medication Management Mental Health Dementia
Review and Evaluation of Mobile Technology to Reduce Medication Burden in Older People
Aston University Prof Ian Maidment πŸŽ“ Nursing & Health

Explore how mobile technology can ease medication burden for older adults. Conduct realist reviews and interviews to develop policies and technology designs that improve medication management in aging populations.

This research addresses the critical challenge of polypharmacy in older adults, a growing issue that complicates health management and incr…

8044+ citations Β· h41
Medication Management Mental Health Dementia
Co-Producing an Intersectional Stigma Reduction Programme for People in the Criminal Justice System with Mental Health Issues
University of Greenwich London, United Kingdom Dr Sarah Kilbane πŸŽ“ Criminology πŸŽ“ Social Work

Explore how to co-produce a stigma reduction program with people in the criminal justice system who experience mental health issues. Investigate intersectional stigma and use mixed methods to develop and pilot an eviden…

This research addresses critical societal barriers faced by individuals in the criminal justice system living with mental health conditions…

19+ citations Β· h3
Forensic Mental Health Stigma Altruistic Fear Food Terrorism
Autonomous Resilience in Heterogeneous IoT Networks
Newcastle University Dr. Yinhao Li πŸŽ“ Artificial Intelligence πŸŽ“ Computer Science Deadline: 13 May 2026

Explore developing autonomous fault diagnosis and self-healing systems for large-scale heterogeneous IoT networks. Apply advanced AI techniques such as federated learning and graph neural networks combined with blockcha…

This research addresses critical challenges in ensuring reliability and autonomous fault recovery in large, heterogeneous IoT networks, vit…

431+ citations Β· h11
Internet of Things Cloud Computing Big Data Analysis Cybersecurity
Optimising Creatine Dosing Strategies for Brain Health in Mild Traumatic Brain Injury
Manchester Metropolitan University Prof Craig Sale πŸŽ“ Biological Sciences πŸŽ“ Neuroscience Deadline: 22 May 2026

Explore how creatine dosing can be optimized to support brain recovery after mild traumatic brain injury. Conduct human trials using advanced imaging and cognitive testing to inform nutritional strategies with potential…

This research addresses a critical gap in understanding how creatine supplementation can improve brain health following mild traumatic brai…

13716+ citations Β· h58
Creatine Supplementation Brain Energy Metabolism Mild Traumatic Brain Injury Dosing Strategies
Optimising Creatine Dosing Strategies for Brain Health in Mild Traumatic Brain Injury
Manchester Metropolitan University Prof Craig Sale πŸŽ“ Biological Sciences πŸŽ“ Neuroscience Deadline: 22 May 2026

Investigate how creatine dosing affects brain health after mild traumatic brain injury. Utilize human trials and advanced brain imaging to discover effective supplementation strategies that could improve clinical outcom…

This research addresses a critical need to optimise brain recovery strategies after mild traumatic brain injury through nutritional interve…

13716+ citations Β· h58
Creatine Supplementation Brain Energy Metabolism Mild Traumatic Brain Injury Cognitive Assessment
Optimising Creatine Dosing Strategies for Brain Health with a Focus on Mild Traumatic Brain Injury
Manchester Metropolitan University Prof Craig Sale πŸŽ“ Biological Sciences πŸŽ“ Neuroscience Deadline: 22 May 2026

Explore how creatine supplementation can be optimised to support brain health, especially after mild traumatic brain injury. Combine human trials and brain imaging to discover effective dosing strategies that improve br…

This research is vital for improving clinical approaches to brain injury recovery, offering potential new nutritional guidelines that could…

13716+ citations Β· h58
Creatine Supplementation Mild Traumatic Brain Injury Brain Energy Metabolism Neuroprotection
Developing charge-aware machine learning potential for electrochemical applications
Imperial College London Dr Jing Yang πŸŽ“ Artificial Intelligence πŸŽ“ Computational Chemistry Deadline: 31 Mar 2026

This PhD focuses on developing charge-aware machine learning interatomic potentials for electrochemical applications, enabling accurate modelling of electrocatalytic systems with long-range electrostatic interactions.

European Research Council part-funded PhD Studentship: β€œDeep Learning-Based Synthetic Histology for Microstructural MRI Biomarkers of the Liver
King’s College London Dr Andrada Ianus, Dr Cheng Zhang πŸŽ“ Biomedical Engineering πŸŽ“ Computer Science Deadline: 17 Apr 2026

Part-funded 3-year PhD at King’s College London focused on combining deep learning and computational histology to develop novel MRI biomarkers for liver micrometastases detection.